Open AccessActivation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1
Author(s) -
Qudong Lu,
Yang Yang,
Hengshuai Zhang,
Cheng Chen,
Jiang Zhao,
Zhenxing Yang,
Fan Yi,
Longkun Li,
Huan Feng,
Jingzhen Zhu,
Shanhong Yi
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s329507
Subject(s) - trpv1 , gpr18 , pharmacology , cannabinoid , medicine , dorsal root ganglion , cannabinoid receptor , interstitial cystitis , resiniferatoxin , chemistry , endocrinology , agonist , transient receptor potential channel , receptor , spinal cord , urinary system , psychiatry
Hyperalgesia and bladder overactivity are two main symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS). Cannabinoid receptors participate in the modulation of pain and bladder function. GPR18, a member of the cannabinoid receptor family, also participates in the regulation of pain and bladder function, but its underlying mechanisms are unknown. In this work, we sought to study the role of GPR18 in IC/BPS.