Open AccessAn Integrated Analysis of Network Pharmacology and Experimental Validation to Reveal the Mechanism of Chinese Medicine Formula Naotaifang in Treating Cerebral Ischemia-Reperfusion Injury
Author(s) -
Tong Yang,
Xiangyu Chen,
Zhigang Mei,
Xiaolu Liu,
Zhaoyong Feng,
Jun Liao,
Yuewen Deng,
Jinwen Ge
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s328837
Subject(s) - kegg , neuroprotection , ischemia , pi3k/akt/mtor pathway , pharmacology , stroke (engine) , ischemic stroke , medicine , in vivo , brain ischemia , neuroscience , signal transduction , biology , gene expression , gene , gene ontology , biochemistry , mechanical engineering , microbiology and biotechnology , engineering
Cerebral ischemia-reperfusion injury (CIRI) is a crucial factor leading to a poor prognosis for ischemic stroke patients. As a novel Chinese medicine formula, Naotaifang (NTF) was proven to exhibit a neuroprotective effect against ischemic stroke, clinically, and to alleviate CIRI in animals. However, the mechanisms underlying the beneficial effect have not been fully elucidated.