Open AccessGellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin Hydrochloride and Clove Oil for Possible Treatment of Periodontitis
Author(s) -
Aiqin Li,
Ifrah Nabi Khan,
Ikram Ullah Khan,
Abid Mehmood Yousaf,
Yasser Shahzad
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s328722
Subject(s) - gellan gum , bilayer , ciprofloxacin hydrochloride , periodontitis , folding endurance , swelling , materials science , aggregatibacter actinomycetemcomitans , buccal administration , chemistry , antibiotics , polymer , food science , pharmacology , medicine , dentistry , ethyl cellulose , composite material , ciprofloxacin , biochemistry , porphyromonas gingivalis , membrane
Periodontitis is a widely spread oral infection and various antibiotics are utilized for its treatment, but high oral doses and development of antibiotic resistance limit their use. This study was aimed at development of natural polymer-based mucoadhesive bilayer films loaded with moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially combat bacterial infection associated with periodontitis.