Open AccessIdentification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification
Author(s) -
Wenwen Chen,
Lin He,
Zhong Liu,
Jiayi Sun,
Lilin Zhang,
Daneng Wei,
Chunjie Wu
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s328333
Subject(s) - mmp3 , mmp1 , decoction , mmp9 , ulcerative colitis , mmp2 , chemistry , matrix metalloproteinase , colitis , kegg , pharmacology , traditional medicine , medicine , downregulation and upregulation , pathology , gene expression , biochemistry , gastroenterology , gene , gene ontology , disease
Huangtu decoction (HTD) has been widely used in the treatment of gastrointestinal bleeding, ulcerative colitis (UC) and gastrointestinal tumors in China, but its active compounds and mechanism are still not clear yet. The present research aimed to identify the active compounds and mechanism of HTD for the treatment of UC.