Open AccessModeling and Simulation for Individualized Therapy of Amisulpride in Chinese Patients with Schizophrenia: Focus on Interindividual Variability, Therapeutic Reference Range and the Laboratory Alert Level
Author(s) -
Shanqing Huang,
Lü Li,
Zhanzhang Wang,
Tao Xiao,
Xin Li,
Shujing Liu,
Ming Zhang,
Haoyang Lu,
Yuguan Wen,
Dewei Shang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s327506
Subject(s) - amisulpride , nonmem , therapeutic drug monitoring , schizophrenia (object oriented programming) , population , medicine , pharmacokinetics , goodness of fit , covariate , pharmacology , statistics , clozapine , psychiatry , mathematics , environmental health
To explain the high inter-individual variability (IIV) and the frequency of exceeding the therapeutic reference range and the laboratory alert level of amisulpride, a population pharmacokinetic (PPK) model in Chinese patients with schizophrenia was built based on therapeutic drug monitoring (TDM) data to guide individualized therapy.