Open AccessDetermination of the 90% Effective Dose of Phenylephrine Boluses to Treat Spinal Anesthesia-Induced Hypotension in Patients with Severe Preeclampsia during Cesarean Delivery: A Pilot Study
Author(s) -
Jinping Liu,
Zheng-Bin Pan,
Miao Zhu,
Guo-wei Zhu,
Da-Bing Song,
Xinzhong Chen,
Xiaowei Qian
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s323715
Subject(s) - medicine , anesthesia , phenylephrine , preeclampsia , bradycardia , bolus (digestion) , blood pressure , pregnancy , surgery , heart rate , biology , genetics
Treatment of spinal anesthesia-induced hypotension in patients with severe preeclampsia assumes special concern as hypotension may further reduce placental perfusion. Phenylephrine is still the first-line vasopressor for treating spinal anesthesia-induced hypotension. However, the optimal dose of phenylephrine used as intravenous (IV) boluses in patients with severe preeclampsia has not been clearly determined. We aim to calculate the 90% effective dose (ED 90 ) of phenylephrine as IV boluses for treating spinal anesthesia-induced hypotension in patients with severe preeclampsia undergoing cesarean delivery.