Open AccessSelection of DNA Aptamers Recognizing EpCAM-Positive Prostate Cancer by Cell-SELEX for in vitro and in vivo MR Imaging
Author(s) -
Jinman Zhong,
Jinli Ding,
Lisheng Deng,
Xiangxian Ying,
Duoduo Liu,
Yanyan Zhang,
Xin Chen,
Quanxin Yang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s322854
Subject(s) - aptamer , systematic evolution of ligands by exponential enrichment , epithelial cell adhesion molecule , chemistry , in vivo , oligonucleotide , molecular imaging , molecular beacon , microbiology and biotechnology , molecular probe , biophysics , cancer research , biology , cell , biochemistry , dna , rna , gene
The sensitive and specific detection of pathogenic cells is important in tumor diagnosis at an early stage. Aptamers are short single-stranded oligonucleotides evolved from systematic evolution of ligands by exponential enrichment (SELEX). It has been proved that aptamers can interact with cognate target molecules with high affinity and specificity and have great potential in the development of medical imaging at molecular level.