Open AccessStarch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer
Author(s) -
Ahmed Gardouh,
Ahmed S.G. Srag El-Din,
Mohamed S. H. Salem,
Yasser M. Moustafa,
Shadeed Gad
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s321962
Subject(s) - bioavailability , differential scanning calorimetry , adme , chemistry , solubility , zeta potential , materials science , nanoparticle , biochemistry , organic chemistry , pharmacology , in vitro , nanotechnology , medicine , physics , thermodynamics
This research aimed to improve water solubility and oral bioavailability of a newly synthesized thienopyrimidine derivative (TPD) with anti-pancreatic cancer activity by loading on starch nanoparticles (SNPs).