Open AccessEffectiveness and Anticancer Activity of a Novel Phenolic Compound from Garcinia porrecta Against the MCF-7 Breast Cancer Cell Line in vitro and in silico
Author(s) -
Darwati Darwati,
Ayu Nadila Safitri,
Nurul Ambardhani,
Tri Mayanti,
Nurlelasari Nurlelasari,
Dikdik Kurnia
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s321824
Subject(s) - mcf 7 , doxorubicin , mtt assay , pharmacology , clusiaceae , chemistry , in silico , estrogen receptor , estrogen receptor alpha , ic50 , cancer , cancer cell , traditional medicine , in vitro , breast cancer , biochemistry , biology , medicine , chemotherapy , genetics , human breast , gene
Cancer is a leading cause of death worldwide, with breast cancer being the most common invasive cancer type in women. Several therapeutic strategies have been explored to reduce the mortality rates of breast cancer. Chemotherapy is the most commonly used systemic treatment, but associated with numerous side-effects. Development of anticancer agents with high efficacy and minimal negative effects is therefore an important focus of research. Natural materials provide an excellent source of bioactive compounds. For instance, Garcinia porrecta from the Clusiaceae family has multiple pharmacological activities, including antioxidant, anti-inflammatory, antibacterial, antiviral, anti-HIV, antidepressant, and anticancer properties.