Open AccessNovel Anti-Tubulin Compounds from Trigonella foenum-graecum Seeds; Insights into In-vitro and Molecular Docking Studies
Author(s) -
Sahar S. Alghamdi,
Rasha Saad Suliman,
Amjad Sulaiman Alsaeed,
Khlood Khaled Almutairi,
Norah Abdulaziz Aljammaz,
Abdulelah Altolayyan,
Rizwan Ali,
Alshaimaa Alhallaj
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s320793
Subject(s) - phytochemical , trigonella , isoflavonoid , chemistry , docking (animal) , traditional medicine , mcf 7 , adme , flavonoid , ic50 , pharmacology , in vitro , biochemistry , cancer cell , biology , cancer , medicine , antioxidant , nursing , human breast , genetics
Fenugreek, also known as Trigonella foenum-graecum L, is a natural plant that belongs to the Fabaceae family and has been known as a promising source of bioactive compounds. It has been widely used as traditional medicine since it has shown to lower blood glucose, manage cholesterol levels and further aid in the prevention and treatment of cancer. Herein, we aim to evaluate the anticancer activity of methanolic fenugreek seed extract against several cancer cell lines.