Open AccessQing-Luo-Yin Alleviated Monocytes/Macrophages-Mediated Inflammation in Rats with Adjuvant-Induced Arthritis by Disrupting Their Interaction with (Pre)-Adipocytes Through PPAR-γ Signaling
Author(s) -
Rui Wang,
Danfeng Li,
Yifang Hu,
Qiang Liao,
Tiantian Jiang,
Opeyemi Joshua Olatunji,
Kui Yang,
Jian Zuo
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s320599
Subject(s) - inflammation , peroxisome proliferator activated receptor , signal transduction , medicine , arthritis , adjuvant , receptor , immunology , pharmacology , cancer research , biology , microbiology and biotechnology
The Chinese herbal formula Qing-Luo-Yin (QLY) has been successfully used in rheumatoid arthritis treatment for decades. It exhibits notable immune and metabolism regulatory properties. Thereby, we investigated its effects on the interplay between (pre)-adipocytes and monocytes/macrophages under adjuvant-induced arthritis (AIA) circumstances.