Open AccessIn vitro Comparison of Pancreatic Enzyme Preparations Available in the Indian Market
Author(s) -
Shailesh V. Shrikhande,
VG Mohan Prasad,
J. Enrique DomínguezMuñoz,
Kevin Weigl,
Kushal Sarda
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s319949
Subject(s) - lipase , enzyme , chemistry , pancreatic enzymes , pancreatic lipase , particle size , dissolution , chromatography , kinetics , enzyme assay , pharmacology , biochemistry , medicine , physics , organic chemistry , quantum mechanics
Pancreatic enzyme replacement therapy (PERT) involves exogenous enzyme supplementation and is used in the treatment of pancreatic exocrine insufficiency. Clinical efficacy of PERT preparations is a function of physical properties and release kinetics that vary between commercially available products. In this study, we evaluated the physical properties, in vitro dissolution, and release kinetics of commercially available pancreatic enzyme preparations available in the Indian market.