Open AccessBi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress
Author(s) -
Ye Eun Kim,
Dong Hwan Kim,
A. Choi,
Seoul Jang,
Kwiwan Jeong,
Youngmi Kim,
Taegyu Nam
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s319287
Subject(s) - endoplasmic reticulum , tunicamycin , unfolded protein response , chemistry , aryl , salicylic acid , stereochemistry , pharmacology , biochemistry , medicine , organic chemistry , alkyl
Endoplasmic reticulum (ER) stress condition is characterized as the accumulation of misfolded or unfolded proteins in lumen of ER. This condition has been implicated in various diseases and pathologies including β-cell apoptosis, Alzheimer's disease and atherosclerosis. We have reported that hydroxynaphthoic acids (HNA), naphthalene analogues of salicylic acid (SA), reduced ER stress. In this study, we explored structural modification to bi-aryl analogues of SA.