Open AccessDual-Functional Peptide Driven Liposome Codelivery System for Efficient Treatment of Doxorubicin-Resistant Breast Cancer
Author(s) -
Kamel S. Ahmed,
Shenhuan Liu,
Jing Mao,
Jie Zhang,
Lipeng Qiu
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s317454
Subject(s) - doxorubicin , liposome , doxorubicin hydrochloride , multiple drug resistance , cytotoxicity , cancer cell , drug delivery , pharmacology , peptide , chemistry , cancer research , cancer , in vitro , chemotherapy , medicine , biochemistry , antibiotics , organic chemistry
The active-targeted drug delivery systems had attracted more and more attention to efficiently overcome multidrug resistance (MDR) in cancer treatments. The aim of the work was to develop a multifunctional nano-structured liposomal system for co-delivery of doxorubicin hydrochloride (DOX) and celecoxib (CEL) to overcome doxorubicin resistance in breast cancer.