Open AccessBardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo
Author(s) -
Zhiying Pang,
Zengxin Jiang,
Runwen Zhu,
Chun Song,
Han Tang,
Lu Cao,
Changan Guo
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s314767
Subject(s) - oxidative stress , chemistry , chondrocyte , aggrecan , apoptosis , cartilage , ex vivo , superoxide dismutase , malondialdehyde , in vivo , pharmacology , reactive oxygen species , osteoarthritis , microbiology and biotechnology , biochemistry , in vitro , medicine , biology , pathology , anatomy , alternative medicine , articular cartilage
Oxidative stress-induced chondrocyte apoptosis and extracellular matrix (ECM) degradation plays an important role in the progression of osteoarthritis (OA). Bardoxolone methyl (BM), a semisynthetic triterpenoid, exerts strong effect against oxidative stress. The purpose of the present study was to determine the effectiveness of bardoxolone-methyl (BM) in preventing oxidative stress-induced chondrocyte apoptosis and extracellular ECM degradation in vitro and the role of alleviating OA progression in vivo.