Open AccessSimultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics
Author(s) -
Jie Hu,
Xin-juan Su,
Hui-Ling Si,
Ruixiang Song,
Fang Zhang,
Xiangjun Qiu,
Xingpeng Chen
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s314562
Subject(s) - chromatography , chemistry , high performance liquid chromatography , pharmacokinetics , selected reaction monitoring , formic acid , beagle , mass spectrometry , tandem mass spectrometry , pharmacology , medicine
An efficient, fast and sensitive ultra high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) method for simultaneous determination of celecoxib (CEL), dezocine (DEZ) and dexmedetomidine (DEX) in beagle plasma were established.