Open AccessEffect of a 2-HP-β-Cyclodextrin Formulation on the Biological Transport and Delivery of Chemotherapeutic PLGA Nanoparticles
Author(s) -
Kangyu Zheng,
Zeju Huang,
Jiaying Huang,
Xiangmei Liu,
Junfeng Ban,
Xin Huang,
Haosen Luo,
Zhicong Chen,
Qiuling Xie,
Yanzhong Chen,
Zhufen Lu
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s314361
Subject(s) - plga , chemistry , cytotoxicity , paclitaxel , in vivo , biodistribution , drug delivery , mtt assay , nanoparticle , drug carrier , pharmacokinetics , in vitro , pharmacology , biophysics , nanotechnology , materials science , biochemistry , cancer , organic chemistry , medicine , microbiology and biotechnology , biology
The aim of this work was to develop a novel and feasible modification strategy by utilizing the supramolecular effect of 2-hydroxypropyl-beta-cyclodextrin (2-HP-β-CD) for enhancing the biological transport efficiency of paclitaxel (PTX)-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles.