Open AccessBaicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats
Author(s) -
Jiali Yang,
Zhixia Jia,
Zhifeng Xiao,
Jing Zhao,
Ye Lu,
Chu Li,
Hui Shao,
Pei Lin,
Shaodan Zhang,
Yuan Chen
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s314076
Subject(s) - pentylenetetrazol , neuroprotection , neurodegeneration , epilepsy , medicine , pharmacology , neuroscience , neun , anticonvulsant , psychology , disease , immunohistochemistry
This study aims to evaluate the beneficial effects of anti-epileptic mechanisms of baicalin (BA) on cognitive dysfunction and neurodegeneration in pentylenetetrazol (PTZ)-induced epileptic rats.