Open AccessTotal Flavone of Abelmoschus manihot Ameliorates Stress-Induced Microbial Alterations Drive Intestinal Barrier Injury in DSS Colitis
Author(s) -
Rong Wang,
Tuo Chen,
Qiong Wang,
Xiaomin Yuan,
Zhenglan Duan,
Zeyu Feng,
Yang Ding,
Fan Bu,
GuoPing Shi,
Yugen Chen
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s313150
Subject(s) - gut flora , ulcerative colitis , context (archaeology) , colitis , medicine , pharmacology , depression (economics) , gastroenterology , immunology , biology , disease , paleontology , macroeconomics , economics
Total flavone of Abelmoschus manihot (TFA), the effective constituents extracted from Flos Abelmoschus Manihot , has been reported to inhibit inflammation. However, the effect of TFA on ulcerative colitis (UC) progression in patients with depression is unknown. The purpose of our research was to explore the anti-UC effects of TFA in the context of depression in mice with UC by regulating the gut microbiota to drive the intestinal barrier.