Open AccessProspective Application of Two New Pyridine-Based Zinc (II) Amide Carboxylate in Management of Alzheimer’s Disease: Synthesis, Characterization, Computational and in vitro Approaches
Author(s) -
Rehman Zafar,
Humaira Naureen,
Muhammad Zubair,
Khadija Shahid,
Muhammad Saeed Jan,
Samar Akhtar,
Hammad Ahmad,
Wajeeha Waseem,
Ali Haider,
Saqib Ali,
Muhammad Tariq,
Abdul Sadiq
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s311619
Subject(s) - chemistry , butyrylcholinesterase , acetylcholinesterase , dpph , cholinesterase , amide , trolox , antioxidant , stereochemistry , combinatorial chemistry , aché , biochemistry , pharmacology , enzyme , medicine
Alzheimer's disease (AD) is a neurodegenerative illness described predominantly by dementia. Even though Alzheimer's disease has been known for over a century, its origin remains a mystery, and researchers are exploring many therapy options, including the cholinesterase technique. A decreased acetylcholine ACh neurotransmitter level is believed to be among the important factors in the progression of Alzheimer's disease.