Open AccessWogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways
Author(s) -
Lei Lei,
Jing Zhao,
Xue-Qi Liu,
Juan Chen,
Xiangming Qi,
Lingling Xia,
Yuangang Wu
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s310882
Subject(s) - wogonin , pi3k/akt/mtor pathway , diabetic nephropathy , protein kinase b , inflammation , medicine , pharmacology , autophagy , kidney , signal transduction , chemistry , apoptosis , pathology , biochemistry , scutellaria baicalensis , alternative medicine , traditional chinese medicine
Kidney tubular epithelial injury is one of the key factors in the progression of diabetic nephropathy (DN). Wogonin is a kind of flavonoid, which has many pharmacological effects, such as anti-inflammation, anti-oxidation and anti-fibrosis. However, the effect of wogonin in renal tubular epithelial cells during DN is still unknown.