Open AccessSilver Nanoparticle-Coated Ethyl Cellulose Inhibits Tumor Necrosis Factor-α of Breast Cancer Cells
Author(s) -
Ahmed A. H. Abdellatif,
Mansour Alsharidah,
Osamah Al Rugaie,
Hesham M. Tawfeek,
Nahla Sameh Tolba
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s310760
Subject(s) - tumor necrosis factor alpha , ethyl cellulose , silver nanoparticle , cytotoxicity , cancer cell , breast cancer , mcf 7 , cytokine , cancer , cancer research , chemistry , necrosis , medicine , materials science , immunology , human breast , nanoparticle , in vitro , pathology , nanotechnology , biochemistry , polymer , organic chemistry
Cancer is one of the leading causes of death worldwide. In many cases, cancer is related to the elevated expression of a significant cytokine known as tumor necrosis factor-α (TNF-α). Breast cancer in particular is linked to increased proliferation of tumor cells, high incidence of malignancies, more metastases, and generally poor prognosis for the patient. The research sought to assess the effect of silver nanoparticles reduced with ethyl cellulose polymer (AgNPs-EC) on TNF-α expression in MCF-7 human breast cancer cells.