Open AccessIcariin, an Up-and-Coming Bioactive Compound Against Neurological Diseases: Network Pharmacology-Based Study and Literature Review
Author(s) -
Shuangqiu Wang,
Jiarui Ma,
Yanqi Zeng,
Guowei Zhou,
Yuxuan Wang,
Wenjuan Zhou,
Xiaohe Sun,
Minghua Wu
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s310686
Subject(s) - icariin , kegg , medicine , disease , spastic , pharmacology , multiple sclerosis , epimedium , bioinformatics , gene ontology , gene , biology , physical therapy , traditional chinese medicine , psychiatry , alternative medicine , pathology , biochemistry , gene expression , cerebral palsy
Icariin is a biologically active substance in Epimedii herba that is used for the treatment of neurologic disorders. However, a comprehensive analysis of the molecular mechanisms of icariin is lacking. In this review, we present a brief history of the use of icariin for medicinal purposes; describe the active chemical components of Epimedii herba ; and examine the evidence from experimental studies that have uncovered molecular targets of icariin in different diseases. We also constructed a protein-protein interaction network and carried out Gene Ontology and Kyoto Encyclopedia of Genes and Genomes functional enrichment analyses to predict the therapeutic actions of icariin in nervous system diseases including Alzheimer disease, Parkinson disease, ischemic stroke, depressive disorder, multiple sclerosis, glioblastoma, and hereditary spastic paraplegias. The results of our analyses can guide future studies on the application of icariin to the treatment of neurologic disorders.