Open AccessInhibitory Effect of Lactococcus lactis subsp. lactis HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway
Author(s) -
Qian Tan,
Jing Hu,
Yujing Zhou,
Yunxiao Wan,
Chuanlan Zhang,
Xin Liu,
Xingyao Long,
Fang Tan,
Xin Zhao
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s309675
Subject(s) - lactococcus lactis , constipation , medicine , vasoactive intestinal peptide , endocrinology , biology , pharmacology , neuropeptide , bacteria , receptor , lactic acid , genetics
The naturally fermented yak yogurt of pastoralists in the Tibetan Plateau, China, because of its unique geographical environment and the unique lifestyle of Tibetan pastoralists, is very different from other kinds of sour milk, and the microorganisms it contains are special. Lactococcus lactis subsp. lactis HFY14 (LLSL-HFY14) is a new lactic acid bacterium isolated from naturally fermented yak yogurt. The purpose of this study was to study the inhibitory effect of the bacterium on constipation.