Open AccessAn Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism of Cuscutae Semen-Mori Fructus Coupled-Herbs in Treating Oligoasthenozoospermia
Author(s) -
Xue Bai,
Yu-Wen Tang,
Qiang Li,
Dan Liú,
Guimin Liu,
Xiaolei Fan,
Zhejun Liu,
Shujun Yu,
Tian Tang,
Shuyan Wang,
Lingru Li,
Kailin Zhou,
Yanfei Zheng,
Zhenquan Liu
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s307015
Subject(s) - kaempferol , silibinin , pharmacology , docking (animal) , computational biology , chemistry , biology , medicine , quercetin , biochemistry , nursing , antioxidant
One of the most common types of male infertility is recognized as oligoasthenozoospermia (OA), characterized by low sperm count and quality in males. As a traditional Chinese medicine (TCM), Cuscutae Semen-Mori Fructus coupled-herbs (CSMFCH) has been known to act a curative effect on OA for thousands of years. Nevertheless, the substantial basis and molecular mechanism of CSMFCH in treating OA remain elusive.