Open AccessCombination Therapy of Metastatic Castration-Recurrent Prostate Cancer: Hyaluronic Acid Decorated, Cabazitaxel-Prodrug and Orlistat Co-Loaded Nano-System
Author(s) -
Zhen Qu,
Yuning Ren,
Huan Shen,
Huihui Wang,
Lijie Shi,
Deyong Tong
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s306684
Subject(s) - cabazitaxel , prodrug , in vivo , pharmacology , chemistry , prostate cancer , toxicity , cancer , medicine , androgen deprivation therapy , biology , organic chemistry , microbiology and biotechnology
Prostate cancer (PCa) is the second leading cause of cancer-related death among men in developed countries. Cabazitaxel (CBZ) is recommended as one of the most active chemotherapy agents for PCa. This study aimed to develop a hyaluronic acid (HA) decorated, cabazitaxel-prodrug (HA-CBZ) and orlistat (ORL) co-loaded nano-system against the prostate cancer in vitro and in vivo.