Open AccessDevelopment of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats
Author(s) -
Suili Yang,
Xiaoshan Zhang,
Yuzhen Wang,
Congcong Wen,
Chenxiang Wang,
Ziye Zhou,
GenMin Lin
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s301241
Subject(s) - posaconazole , dasatinib , pharmacokinetics , chemistry , pharmacology , chromatography , bioanalysis , tyrosine kinase inhibitor , medicine , tyrosine kinase , cancer , amphotericin b , antifungal , biochemistry , receptor , dermatology
Dasatinib is approved for the treatment of leukaemia worldwide. Triazole agents such as posaconazole may be used for the control of secondary fungal infection with leukaemia. This work aimed to develop a bioanalytical method to study the potential interaction between dasatinib and posaconazole.