Open AccessHydroxyapatite Nanoparticles Facilitate Osteoblast Differentiation and Bone Formation Within Sagittal Suture During Expansion in Rats
Author(s) -
Wei Liang,
Pengbing Ding,
Li Guan,
Enhang Lu,
Zhihui Zhao
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s299641
Subject(s) - osteoblast , sagittal suture , fibrous joint , distraction osteogenesis , saline , medicine , sagittal plane , chemistry , anatomy , surgery , in vitro , biology , distraction , biochemistry , neuroscience
The potential of relapse of craniofacial disharmony after trans-sutural distraction osteogenesis is high due to the failure to produce a stable bone bridge in the suture gap. The aim of this study is to evaluate whether hydroxyapatite nanoparticles (nHAP) have the effect of promoting osteoblast differentiation of suture-derived stem cells (SuSCs) and bone formation in sagittal suture during expansion.