Open AccessPreparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery
Author(s) -
Yifan Wang,
Si Chen,
Xin Yang,
Shuang Zhang,
Chunying Cui
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s299479
Subject(s) - bovine serum albumin , survivin , chemistry , in vivo , bicinchoninic acid assay , small interfering rna , plga , mtt assay , microbiology and biotechnology , in vitro , pharmacology , transfection , biochemistry , apoptosis , medicine , biology , gene
siRNA brings hope for cancer therapy. However, there are many obstacles for application of siRNA in clinical. Because of the excellent biocompatibility, non-toxicity and non-immunogenicity of bovine serum albumin (BSA), BSA-based nanoparticles have been widely designed as a drug carrier system.