Open AccessDevelopment and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients
Author(s) -
Muhammad Nasir Kalam,
Muhammad Fawad Rasool,
Faleh Alqahtani,
Imran Imran,
Asim Ur Rehman,
Naveed Ahmed
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s297981
Subject(s) - physiologically based pharmacokinetic modelling , cirrhosis , propranolol , dosing , pharmacokinetics , liver disease , medicine , pharmacology , drug
The study was aimed to understand the underlying causes for the differences in propranolol pharmacokinetics (PK) between healthy and cirrhosis populations by using a systematic whole-body physiologically based pharmacokinetic (PBPK) model-building approach for suggesting model informed propranolol dosing in liver cirrhosis patients with different stages of disease severity.