Open AccessNetwork Pharmacology Analysis of ZiShenWan for Diabetic Nephropathy and Experimental Verification of Its Anti-Inflammatory Mechanism
Author(s) -
Xiaoyuan Guo,
You Wu,
Zhang Chengfei,
Lili Wu,
Lingling Qin,
Tonghua Liu
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s297683
Subject(s) - kegg , inflammation , pharmacology , tumor necrosis factor alpha , systems pharmacology , diabetic nephropathy , signal transduction , medicine , biology , bioinformatics , kidney , immunology , gene expression , microbiology and biotechnology , gene , drug , gene ontology , biochemistry
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The inflammatory response plays a critical role in DN. ZiShenWan (ZSW) is a classical Chinese medicinal formula with remarkable clinical therapeutic effects on DN, but its pharmacological action mechanisms remain unclear.