Open AccessChlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis
Author(s) -
Jiacheng Zhou,
Fengqi Zhang,
Jun Chen,
Shilin Zhang,
Haijun Wang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s296862
Subject(s) - apoptosis , cell growth , cell cycle , glioma , annexin , in vivo , signal transduction , pharmacology , chemistry , biology , cancer research , microbiology and biotechnology , biochemistry
Chlorogenic acid (CGA) is a type of polyphenolic substance that is widely extracted from many traditional Chinese medicines (eg, Lonicera japonica Thunb, Eucommia ulmoides Oliver) and exhibits a wide range of anti-tumor effects. However, the potential molecular mechanisms of CGA in glioma U373 cells remain unclear.