Open AccessCharge-Transfer Complex of Linifanib with 2,3-dichloro-3,5-dicyano-1,4-benzoquinone: Synthesis, Spectroscopic Characterization, Computational Molecular Modelling and Application in the Development of Novel 96-microwell Spectrophotometric Assay
Author(s) -
Ibrahim A. Darwısh,
Nasr Y. Khalil,
Nawaf A. Alsaif,
Rashed N. Herqash,
Ahmed Y A Sayed,
Hamdy M. AbdelRahman
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s296502
Subject(s) - stoichiometry , chemistry , molecule , analytical chemistry (journal) , chromatography , organic chemistry
Linifanib (LFB) is a multi-targeted receptor tyrosine kinase inhibitor used in the treatment of hepatocellular carcinoma and other types of cancer. The charge-transfer (CT) interaction of LFB is important in studying its receptor binding mechanisms and useful in the development of a reliable CT-based spectrophotometric assay for LFB in its pharmaceutical formulation to assure its therapeutic benefits.