Open AccessEdaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway
Author(s) -
Yang-Liang Yang,
Jing Yi,
Mengzhi Pan,
Baoji Hu,
Honglang Duan
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s294557
Subject(s) - neurotoxicity , tunel assay , terminal deoxynucleotidyl transferase , pharmacology , tropomyosin receptor kinase b , neurotrophic factors , neuroprotection , pi3k/akt/mtor pathway , apoptosis , brain derived neurotrophic factor , chemistry , medicine , receptor , biochemistry , toxicity
To investigate the neuroprotective effect of edaravone on excessive-dose propofol-induced neurotoxicity in the hippocampus of newborn rats and HT22 cells.