Open AccessFTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4+ T Lymphocytes
Author(s) -
Chao Zhu,
Shuang Wen,
Junyong Li,
Hongyu Meng,
Junzhe Zhang,
Kuo Zhao,
Ling Wang,
Yingze Zhang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s293876
Subject(s) - tumor necrosis factor alpha , signal transduction , interleukin , immune system , protein kinase b , chemistry , arthritis , apoptosis , inflammation , microbiology and biotechnology , lymphocyte , pharmacology , cytokine , immunology , medicine , biology , biochemistry
Fingolimod (FTY720), a novel immunomodulator, was found to suppress the severity of collagen-induced arthritis (CIA) in mice. However, the potential molecular mechanisms are still unknown, and the effect of FTY720 on the recruitment of immune cells in the affected joints in the CIA model is not clear.