Open AccessPotential Anti-Coronavirus Agents and the Pharmacologic Mechanisms
Author(s) -
Yang Yang,
Xiao Cui,
Huaying Wei,
Caiping Guo,
Yulin Zhang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s293216
Subject(s) - middle east respiratory syndrome coronavirus , coronavirus , pathogenesis , middle east respiratory syndrome , pathogen , covid-19 , virology , coronaviridae , sars virus , medicine , biology , immunology , disease , infectious disease (medical specialty) , outbreak , pathology
Severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) is an emerging pathogen, which is similar to previous SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV) occurrences. However, we only get few understandings about the pathogenesis of SARS-CoV-2, which need to further be studied. The discovery of an agent that has a treatment efficacy against SARS-CoV-2 is very urgent. In this review, we briefly discuss the virology of this pathogen and focus on the available understanding of the pathogenesis and treatments of this pathogen including the uses of nucleoside analogues, protease inhibitors, interferons, and other small-molecule drugs, on the basis previous comprehensions of SARS and MERS. These reviewed concepts may be beneficial in providing new insights and potential treatments for COVID-19.