Open AccessWithanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model
Author(s) -
Acharya Balkrishna,
Subarna Pokhrel,
Harsh Vikram Singh,
Monali Joshi,
Vallabh Prakash Mulay,
Swati Haldar,
Anurag Varshney
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s292805
Subject(s) - withania somnifera , withaferin a , in silico , docking (animal) , in vitro , transmembrane protein , in vivo , chemistry , microbiology and biotechnology , biology , computational biology , biophysics , biochemistry , medicine , receptor , gene , genetics , alternative medicine , nursing , pathology
SARS-CoV-2 engages human ACE2 through its spike (S) protein receptor binding domain (RBD) to enter the host cell. Recent computational studies have reported that withanone and withaferin A, phytochemicals found in Withania somnifera , target viral main protease (M Pro ) and host transmembrane TMPRSS2, and glucose related protein 78 (GRP78), respectively, implicating their potential as viral entry inhibitors. Absence of specific treatment against SARS-CoV-2 infection has encouraged exploration of phytochemicals as potential antivirals.