Open AccessGeniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway
Author(s) -
Ying Hou,
Peipei Yuan,
Yang Fu,
Qi Zhang,
Liyuan Gao,
Yaxin Wei,
Xiaoke Zheng,
Weisheng Feng
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s292107
Subject(s) - ampk , apoptosis , pharmacology , medicine , cardiac function curve , chemistry , p38 mitogen activated protein kinases , protein kinase a , endocrinology , kinase , biochemistry , heart failure
Hypertension is closely related to myocardial injury. Long-term hypertension can cause myocardial injury. Therefore, it is very important to find drugs to treat myocardial injury caused by hypertension. The aim of present study is to investigate the effects and mechanisms of geniposide on myocardial injuries in spontaneously hypertensive rats (SHR) and H9c2 cells induced by NaCl solution.