Open AccessRole of Oxidative Stress and Reduced Endogenous Hydrogen Sulfide in Diabetic Nephropathy
Author(s) -
Arslan Hussain Lodhi,
Fiaz-ud-Din Ahmad,
Kainat Furwa,
Asadullah Madni
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s291591
Subject(s) - captopril , endocrinology , sodium hydrosulfide , medicine , metformin , diabetic nephropathy , malondialdehyde , oxidative stress , streptozotocin , diabetes mellitus , chemistry , pharmacology , blood pressure , hydrogen sulfide , sulfur , organic chemistry
Persistent hyperglycemia lead towards depletion of hydrogen sulfide (H 2 S) resulting in generation of oxidative stress and diabetic nephropathy. The aim of the current study was to explore the antioxidant potential of H 2 S and captopril, a -SH containing compound in streptozotocin (STZ)-induced diabetic nephropathy.