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Quaternary Lidocaine Derivatives: Past, Present, and Future
Author(s) -
Qi Wang,
Yujun Zhang,
Jin Liu,
Wensheng Zhang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s291229
Subject(s) - lidocaine , electrophysiology , anesthesia , pharmacodynamics , medicine , pharmacology , pharmacokinetics
Local anesthetics have the advantage of complete analgesia with fewer side effects compared to systemic analgesics. However, their clinical use is limited due to their short duration of action. Thus, local anesthetics with fast onset, long duration of action, selective nociceptive block, and low local and systemic toxicity are highly desirable. In the past electrophysiological studies, quaternary lidocaine derivatives (QLDs) showed these characteristics. Here, we review electrophysiological properties of QLDs and their pharmacodynamic characteristics to shed light on potential problems.

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