Open AccessEnhanced Accumulation of Cisplatin in Ovarian Cancer Cells from Combination with Wedelolactone and Resulting Inhibition of Multiple Epigenetic Drivers
Author(s) -
Sadia Sarwar,
Abir Alamro,
Amani Alghamdi,
Komal Naeem,
Salamat Ullah,
Muazzam Arif,
Jun Yu,
Fazlul Huq
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s288707
Subject(s) - cisplatin , ovarian cancer , pharmacology , cancer research , cancer cell , apoptosis , chemistry , medicine , cancer , oncology , chemotherapy , biochemistry
Cisplatin resistance is a major concern in ovarian cancer treatment. The aim of this study was to investigate if wedelolactone could perform better in resistant ovarian cancer cells when used in combination with cisplatin.