Open AccessSynthesis, Radiolabeling, and Preliminary in vivo Evaluation of [68Ga] IPCAT-NOTA as an Imaging Agent for Dopamine Transporter
Author(s) -
ShiouShiow Farn,
Kang-Wei Chang,
Wan-Ting Lin,
Hung-Man Yu,
Kun-Liang Lin,
Yu-Chin Tseng,
Yu Chang,
ChungShan Yu,
Wuu-Jyh Lin
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s288600
Subject(s) - biodistribution , tropane , in vivo , lipophilicity , chemistry , dopamine transporter , positron emission tomography , ex vivo , radiochemistry , in vitro , transporter , pet imaging , nuclear medicine , pharmacology , biochemistry , medicine , stereochemistry , microbiology and biotechnology , gene , biology
Novel radiotracer development for imaging dopamine transporters is a subject of interest because although [ 99m Tc]TRODAT-1, [ 123 I]β-CIT, and [ 123 I]FP-CIT are commercially available; 99 Mo/ 99m Tc generator is in short supply and 123 I production is highly dependent on compact cyclotron. Therefore, we designed a novel positron emission tomography (PET) tracer based on a tropane derivative through C-2 modification to conjugate NOTA for chelating 68 Ga, a radioisotope derived from a 68 Ge/ 68 Ga generator.