Open AccessAloperine Inhibits Proliferation and Promotes Apoptosis in Colorectal Cancer Cells by Regulating the circNSUN2/miR-296-5p/STAT3 Pathway
Author(s) -
Wei Han,
Desong Kong,
Qiong Lu,
Wei Zhang,
Zhimin Fan
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s288473
Subject(s) - stat3 , apoptosis , microrna , colorectal cancer , cancer research , downregulation and upregulation , cell growth , stat protein , gene silencing , biology , chemistry , cancer , gene , biochemistry , genetics
Aloperine can regulate miR-296-5p/Signal Transducer and Activator of Transcription 3 (STAT3) pathway to inhibit the malignant development of colorectal cancer (CRC), but the regulatory mechanism is unclear. This study explored the upstream mechanism of Aloperine in reducing CRC damage from the perspective of the circRNA-miRNA-mRNA regulatory network.