Open AccessLow Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China
Author(s) -
LAI Jinglan,
Yuming Liu,
Xiao Han,
Aiwen Huang,
Jin Lin,
Wen Ao,
Hanhui Ye,
Yahong Chen
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s286863
Subject(s) - integrase , resistance mutation , drug resistance , virology , medicine , elvitegravir , biology , reverse transcriptase , genetics , viral load , virus , polymerase chain reaction , human immunodeficiency virus (hiv) , gene , antiretroviral therapy
With the widespread use of integrase strand transfer inhibitors (INSTIs) in the clinical setting, transmission of INSTIs-resistance mutations may increase. Data regarding transmitted drug resistance mutations (TDRM) to INSTIs in Chinese HIV patients are limited. The aim of this study was to summarize the INSTIs TDRM, including the frequency of protease inhibitors (PIs) and reverse transcriptase (RT) inhibitors (RTIs) mutations in treatment-naïve patients in Southeast China.