Open AccessTotal Glucosides of Paeony Inhibited Autophagy and Improved Acute Kidney Injury Induced by Ischemia-Reperfusion via the lncRNA TUG1/miR-29a/PTEN Axis
Author(s) -
Xiaoyan Chang,
Pei Zhang,
Xingxin Xu,
Bo Pang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s286606
Subject(s) - autophagy , pten , hypoxia (environmental) , acute kidney injury , kidney , downregulation and upregulation , apoptosis , ischemia , creatinine , cancer research , programmed cell death , chemistry , pi3k/akt/mtor pathway , medicine , pharmacology , biochemistry , gene , organic chemistry , oxygen
Total glucosides of paeony (TGP) has been proven to affect anti-inflammatory, immunomodulatory and hypoxia tolerance. This study investigates the effect of TGP on autophagy in acute kidney injury (AKI) induced by ischemia-reperfusion (I/R).