Open AccessVolumetric Absorptive Microsampling as a New Biosampling Tool for Monitoring of Tamoxifen, Endoxifen, 4-OH Tamoxifen and N-Desmethyltamoxifen in Breast Cancer Patients
Author(s) -
Baitha Palanggatan Maggadani,
Harmita,
Samuel J Haryono,
Marcellino Ryan Rinaldi,
Yahdiana Harahap
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s286409
Subject(s) - formic acid , chromatography , chemistry , analyte , tamoxifen , detection limit , breast cancer , medicine , cancer
In this research, we used a volumetric absorptive microsampling (VAMS) technique to collect blood samples from the patients. A rapid and simple sample preparation method and LC-MS.MS assay was then developed and validated for the simultaneous analysis of tamoxifen and its three active metabolites.