Open AccessCaspase Cascade Activation During Apoptotic Cell Death of Human Lung Carcinoma Cells A549 Induced by Marine Sponge Callyspongia aerizusa
Author(s) -
Yuni Elsa Hadisaputri,
Rheza Andika,
Iyan Sopyan,
Ade Zuhrotun,
Rani Maharani,
Rachmaniar Rachmat,
Rizky Abdulah
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s282913
Subject(s) - a549 cell , apoptosis , clonogenic assay , programmed cell death , cell culture , sponge , chemistry , cancer cell , lung cancer , viability assay , microbiology and biotechnology , biology , cancer , biochemistry , medicine , pathology , botany , genetics
In this study, Callyspongia aerizusa (CA), one of the most popular marine sponges for cancer therapy research, was investigated for its phytochemical compounds and evaluated for its anticancer activity in various cell lines. Since lung cancer is the most frequently diagnosed cancer, a solution from this marine source is a good choice to address the resistance to anticancer agents. Elucidation of the underlying mechanism of cell death elicited by a CA extract in human lung carcinoma cells A549 was undertaken.