Open AccessSinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice
Author(s) -
Dong Liu,
Yan-Jun Chen,
Fang Fang Li,
Cunwu Chen,
Peipei Wei,
Deli Xiao,
Bangxin Han
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s282227
Subject(s) - microbubbles , lipopolysaccharide , medicine , ultrasound , lung , pharmacology , immunology , radiology
Pulmonary surfactants (eg, sinapultide) are widely used for the treatment of lung injury diseases; however, they generally induce poor therapeutic efficacy in clinics. In this study, sinapultide-loaded microbubbles (MBs) were prepared and combined with ultrasound (US) treatment as a new strategy for improved treatment of lung injury diseases.