Open Access<p>Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats</p>
Author(s) -
Emad H.M. Hassanein,
Omnia A M Abd El-Ghafar,
Marwa A. Ahmed,
Ahmed M. Sayed,
Wail M. Gad-Elrab,
Jamaan S. Ajarem,
Ahmed A. Allam,
Ayman M. Mahmoud
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s281854
Subject(s) - pi3k/akt/mtor pathway , cardiotoxicity , keap1 , oxidative stress , protein kinase b , pharmacology , edaravone , chemistry , medicine , apoptosis , biochemistry , toxicity , transcription factor , gene
Cyclophosphamide (CP) causes redox imbalance and its use is associated with marked cardiotoxicity that limits its clinical applications. The present study investigated the protective effects of acetovanillone (AV) and edaravone (ED) against CP-induced oxidative stress and cardiac damage, emphasizing the role of PI3K/Akt/mTOR and Nrf2 signaling.