Open Access<p>Agomelatine Attenuates Isoflurane-Induced Inflammation and Damage in Brain Endothelial Cells</p>
Author(s) -
Cheng Fang,
Hebron C. Chang,
Fengfeng Yan,
Aixing Yang,
Jing Liu,
Yuliang Liu
Publication year - 2020
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s281582
Subject(s) - agomelatine , isoflurane , inflammation , pharmacology , medicine , chemistry , hippocampus , anesthesia , antidepressant
Neurotoxicity of anesthetics has been widely observed by clinicians. It is reported that inflammation and oxidative stress are involved in the pathological process. In the present study, we aimed to assess the therapeutic effects of agomelatine against isoflurane-induced inflammation and damage to brain endothelial cells.